Open Research Repository
The Open Research Repository is the University’s online open access repository for collecting, maintaining and disseminating the scholarly output of the University.
Contribute to the Open Research Repository
Communities in DSpace
Select a community to browse its collections.
Recent Submissions
Item type: Publication , Access status: Metadata only , Investigating employee creative performance with integration of DeLone and McLean information system success model and technology acceptance model: The moderating role of creative self-efficacy(2020) Yamin, Mohammad Ali Yousef; Sweiss, Mohammad Ibrahim KamelInternet usage has rapidly become an indispensable adjunct in organisations operations and has improved individuals' daily life. Therefore, the present study develops an integrated model with combination of DeLone and McLean IS model, creative self-efficacy and technology acceptance model in order to investigate employees' actual usage of internet in organisations and its impact on employees' creative performance. This study extends the body of knowledge in this subject and examined the moderating effect of creative self-efficacy between actual use of internet and employee creative performance. For data analysis structural equation modelling (SEM) approach was used. Results indicate that DeLone and McLean and technology acceptance model constructs jointly explained R2 72.0% variance in actual use of internet. Moreover, findings confirmed that creative self-efficacy moderate the relationship between actual use of internet and employee creative performance. The importance level of the constructs was assessed with (f2) effect size and IPMA analysis.Item type: Publication , Access status: Metadata only , Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na⁺ Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening(2025-10-10) Casas, Arturo; Imlay, Leah S.; Thathy, Vandana; Fairhurst, Kate J.; Lehane, Adele M.; Lawong, Aloysus K.; Deni, Ioanna; Striepen, Josefine; Lee, Seungheon; Kumar, Ashwani; Xing, Chao; Niederstrasser, Hanspeter; Posner, Bruce A.; Laleu, Benoît; Charman, Susan A.; Fidock, David A.; Ready, Joseph M.; Phillips, Margaret A.Malaria treatments are compromised by drug resistance, creating an urgent need to discover new drugs. We used a phenotypic high-throughput screening (HTS) platform to identify new antimalarials, uncovering three related pyrrole-, indole-, and indoline-based series with a shared α-azacyclic acetamide core. These compounds showed fast-killing activity on asexual blood-stage Plasmodium falciparum parasites, were not cytotoxic, and disrupted parasite intracellular pH and Na+ regulation similarly to cipargamin (KAE609), a clinically advanced inhibitor of the P. falciparum Na+ pump (PfATP4). PfATP4 is localized to the parasite plasma membrane and is essential for maintaining a low cytosolic Na+ concentration. Resistance selections on P. falciparum parasites with two α-azacyclic acetamide analogs identified mutations in PfATP4, and cross-resistance was observed across the α-azacyclic acetamides and KAE609, confirming PfATP4 as the target. PfATP4 is a well-established antimalarial target, and identification of additional PfATP4 inhibitors provides alternative avenues to disrupt its function.Item type: Publication , Access status: Metadata only , Pile groups under axial loading: An appraisal of simplified non-linear prediction models(2019-07-01) Sheil, Brian B.; McCABE, Bryan A.; Comodromos, Emilios M.; Lehane, Barry M.The settlement behaviour of vertically loaded pile groups has been the subject of an extensive body of research over the past two decades. In particular, this work has identified the over-conservatism associated with predictions of pile interaction derived from elastic theory and the corresponding amplification of group settlement relative to single pile values. Researchers have since redoubled efforts to refine settlement predictions for pile groups towards more economical design, largely through more rigorous treatment of soil stiffness non-linearity. Although foundation design engineers are increasingly employing three-dimensional continuum analyses to quantify pile interaction on a site-specific basis, simplified design approaches remain an integral part of preliminary foundation design. The purpose of this paper is to undertake a critical examination of these methods with a view to increasing their potential for take-up by foundation engineering practitioners. A database of simplified models has been collated for the prediction of non-linear pile interaction that exists within vertically loaded pile groups. These models are categorised as either analytical or empirical. The development, limitations and range of applicability of these models are explored in detail in the context of some published case histories.Item type: Publication , Access status: Metadata only , Effects of a virtual iSupport Program on carers and people with dementia(2025) Xiao, Lily; Ullah, Shahid; Yu, Ying; Meyer, Claudia; Chapman, Michael; Chen, Langduo; Tan, Kai Ping; McKechnie, Sue; Ottaway, Mel; Andrade, Andre Queiroz De; Ratcliffe, Julie; Whitehead, Craig; Tran, Kam; Wang, Yao; Kitson, AlisonINTRODUCTION: We conducted a virtual iSupport Program intervention for carers of people living with dementia (PLWD). METHODS: We applied a pragmatic randomized controlled trial to evaluate a multicomponent program delivered virtually in four organizations (July 2022 to December 2024). The primary outcome was quality of life (QoL) of carers and PLWD at 12 months post-baseline, and the secondary outcomes were carers’ self-efficacy, social support, reactions to behavior, PLWD's behavior frequency, hospital admissions, and emergency department presentations. RESULTS: One hundred forty-nine carers enrolled in the study. The intervention group reported increased mental-health-related QoL points of 12.0 (p < 0.001), self-efficacy points of 14.8 to 18.5 (p < 0.001), social support points of 0.25 (p < 0.028), reduced reactions to behavior points of -0.25 (p < 0.028), and a 60% lower hospital admission rate (p = 0.045) at 12 months compared with the usual care group. DISCUSSION: The virtual iSupport Program showed benefits for both carers and PLWD in a 12-month intervention. TRIAL REGISTRATION: Australia New Zealand Clinical Trials Registry: ACTRN12622000199718. Highlights: A total of 149 dementia carers participated in the virtual iSupport program intervention trial. The program included skills training, peer support, and access to care services. The program improved mental health-related quality of life for carers. The program improved self-efficacy, social support, and reduced distress for carers. The program reduced 60% hospital admission rate for people with dementia.Item type: Publication , Access status: Metadata only , Examining the role of transformational leadership and entrepreneurial orientation on employee retention with moderating role of competitive advantage(2020) Yamin, Mohammad Ali YousefThis study aims to investigate employee motivational and environmental factors and their effects on employee retention and organizational performance. Employee retention is predicted by organizational environment, intrinsic motivation, organizational learning, knowledge management, entrepreneurial orientation, external connect and explained R2=76.3% of the variance in employee retention. Therefore, organizational performance is predicted by competitive advantage and employee retention and explained R2=19.9% of the variance in organizational performance. Effect size analysis indicates that intrinsic motivation had substantial effect on size when compared with other exogenous variables. The predictive relevance of the model was found substantial revealed Q2=40.5% relevance to predict employee retention. The moderating role of the competitive advantage was confirmed and directs that the positive relationship between employee retention and organizational performance will be stronger when competitive advantage is higher. Finally, results showed that intrinsic motivation had the highest importance level when compared with other constructs. Therefore, manager and policy makers should take into consideration intrinsic motivation and transformational leadership in order to boost employee retention and organizational performance.