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Item type: Publication , Access status: Metadata only , ANZSREI consensus statement on elective oocyte cryopreservation(2019-10-01) Lew, Raelia; Foo, Jinny; Kroon, Ben; Boothroyd, Clare; Chapman, MichaelBackground: One in six Australian women and couples suffer infertility. A rising proportion relates to advanced maternal age, associated with poorer oocyte quality and in vitro fertilisation (IVF) outcomes. Internationally, oocyte cryopreservation technology applied to oocytes vitrified before 35 years provides similar live-birth statistics compared to IVF treatment using fresh oocytes. Oocyte cryopreservation is accessible in Australasian settings and elective uptake is increasing. For women accessing treatment, oocyte cryopreservation may expand future family building options. Aims: To develop the first Australasian Certification in Reproductive Endocrinology and Infertility (CREI) subspecialist-led consensus guideline on oocyte cryopreservation. Methods: The ANZSREI ACCEPT (Australasian CREI Consensus Expert Panel on Trial evidence group) met in 2017 and 2018 and identified clinical aspects of care for inclusion and review. Review of the available evidence was conducted and consensus statements prepared. Areas of dissent of expert opinion and for further research were noted. Results: Consensus was reached on definition and best practice in oocyte cryopreservation for freeze method, controlled ovarian stimulation, medical risk reduction and treatment and outcomes counselling. The term ‘social egg freezing’ may marginalise, stigmatise or attribute social blame to women, and there is a need to revise this to a neutral and non-judgemental term such as elective or planned oocyte cryopreservation. Conclusion: Oocyte cryopreservation has the potential to improve cumulative live birth outcomes for women. Implementation of this guideline should facilitate an optimal approach for providing care.Item type: Publication , Access status: Metadata only , The impact of consumer affordability on access to assisted reproductive technologies and embryo transfer practices: An international analysis(2014) Chambers, Georgina M.; Hoang, Van Phuong; Sullivan, Elizabeth A.; Chapman, Michael G.; Ishihara, Osamu; Zegers-Hochschild, Fernando; Nygren, Karl G.; Adamson, G. DavidObjective To systematically quantify the impact of consumer cost on assisted reproduction technology (ART) utilization and numbers of embryos transferred. Design Ordinary least squared (OLS) regression models were constructed to measure the independent impact of ART affordability - measured as consumer cost relative to average disposable income - on ART utilization and embryo transfer practices. Setting Not applicable. Patient(s) Women undergoing ART treatment. Intervention(s) None. Main Outcome Measure(s) OLS regression coefficient for ART affordability, which estimates the independent effect of consumer cost relative to income on utilization and number of embryos transferred. Result(s) ART affordability was independently and positively associated with ART utilization with a mean OLS coefficient of 0.032. This indicates that, on average, a decrease in the cost of a cycle of 1 percentage point of disposable income predicts a 3.2% increase in utilization. ART affordability was independently and negatively associated with the number of embryos transferred, indicating that a decrease in the cost of a cycle of 10 percentage points of disposable income predicts a 5.1% increase in single-embryo transfer cycles. Conclusion(s) The relative cost that consumers pay for ART treatment predicts the level of access and number of embryos transferred. Policies that affect ART funding should be informed by these findings to ensure equitable access to treatment and clinically responsible embryo transfer practices.Item type: Publication , Access status: Metadata only , Numerical investigation of the monotonic drained lateral behaviour of large-diameter rigid piles in medium-dense uniform sand(2021-12-20) Wang, Huan; Fraser Bransby, M.; Lehane, Barry M.; Wang, Lizhong; Hong, YiThis paper presents a numerical investigation of the monotonic lateral response of large-diameter monopiles in drained sand with configurations typical of those employed to support offshore wind turbines. Results: from new centrifuge tests using instrumented monopiles in uniform dry sand deposits are first presented and used to illustrate the suitability of an advanced hypoplastic constitutive model to represent the sand in finite-element analyses of the experiments. These analyses are then extended to examine the influence of pile diameter and loading eccentricity on the lateral response of rigid monopiles. The results show no dependency of suitably normalised lateral load transfer curves on the pile diameter and loading eccentricity. It is also shown that, in a given uniform sand, the profile with depth of net soil pressure at ultimate lateral capacity is independent of the pile diameter because of the insensitivity of the depth to the rotation centre for a rigid pile. A normalisation method is subsequently proposed which unifies the load-deflection responses of rigid piles with different diameters at a given load eccentricity.Item type: Publication , Access status: Metadata only , N-(3-Chloropropionyl)-N'-phenylthiourea(2010) Othman, Eliyanti A.; Soh, Siti K.C.; Yamin, Bohari M.The title compound, C10H11ClN2OS, adopts a cis-trans configuration with respect to the position of the phenyl and 3-chloro-propionyl groups relative to the thiono group across the C - N bonds. The benzene ring is perpendicular to the propionyl thio-urea fragment with a dihedral angle of 82.62 (10)°. An intra-molecular N - H⋯O inter-action occurs. The crystal structure is stabilized by inter-molecular N - H⋯S hydrogen bonds, which link pairs of mol-ecules, building up R 22(8) ring motifs, and C - H. π inter-actions.Item type: Publication , Access status: Metadata only , Examination of the potential of the seismic dilatometer (SDMT) to estimate in situ stiffness decay curves in various soil types(2014-09-01) Amoroso, S.; Monaco, P.; Lehane, B. M.; Marchetti, D.This paper illustrates the use of the seismic dilatometer (SDMT) to assess the decay of in-situ stiffness with strain level in different soil types. The approach adopted in this study relies on the ability of the SDMT to provide routinely at each test depth both a small strain stiffness (G0 from VS) and a working strain stiffness (constrained modulus MDMT derived from the usual DMT interpretation). At various test sites, working strain DMT moduli are compared with reference stiffness decay curves back-figured from (i) the behavior observed under a full-scale test embankment (at Treporti) or footings (in Texas), (ii) from laboratory tests (at L'Aquila, Fucino plain and Po plain) and (iii) various combinations of insitu and laboratory testing techniques (Western Australia). Typical ranges of the shear strains γDMT associated with working strain DMT moduli are inferred to assist construction of stiffness - strain decay curves for different soil types.