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Escherichia coli Glucuronylsynthase: an engineered enzyme for the synthesis of β -glucuronides

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Date

2008

Authors

Wilkinson, Shane M
Liew, Chu W
Mackay, Joel Peter
Salleh, Hamzah M
Withers, Stephen G
McLeod, Malcolm

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step syn

Description

Keywords

Keywords: glucuronide; glucuronosyltransferase; article; biosynthesis; chemistry; enzymology; Escherichia coli; metabolism; protein engineering; Escherichia coli; Glucuronides; Glucuronosyltransferase; Protein Engineering

Citation

URI

http://hdl.handle.net/1885/50972

Collections

Open Access Research

Source

Organic Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ol8002767

Restricted until

2037-12-31

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Description
01_Wilkinson_Escherichia_coli__2008.pdf (75.71 KB)

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