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Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

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Date

2003

Authors

El-Assaad, Wissal
Buteau, Jean
Peyot, Marie-Line
Nolan, Christopher
Roduit, Raphael
Hardy, Serge
Joly, Erik
Dbaibo, Ghassan
Rosenberg, Lawrence
Prentki, Marc

Journal Title

Journal ISSN

Volume Title

Publisher

Endocrine Society (USA)

Abstract

We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because high glucose inhibits fat oxidation and consequently lipid detoxification. Th

Description

Keywords

Keywords: 5 aminoimidazole 4 carboxinamide 1beta dextro ribofuranoside; adenylate kinase; enzyme activator; etomoxir; glucose; ligase inhibitor; linoleic acid; long chain fatty acid coenzyme A ligase; metformin; monounsaturated fatty acid; oleic acid; palmitic acid

Citation

URI

http://hdl.handle.net/1885/18350

Collections

Open Access Research

Source

Endocrinology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1210/en.2003-0410

Restricted until

2037-12-31

Downloads

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Description
01_El-Assaad_Saturated_fatty_acids_2003.pdf (465.61 KB)

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