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Butyrylcholinesterase inhibitory C-glycoside from Symplocos racemosa

Abstract

The re-investigation of the chemical constituents of Symplocos racemosa Roxb. led to the isolation of one new C-glycoside, symcososide (1) along with one known compound β-sito-glycoside (2). The structure of the new compound was determined by 1D and 2D-homonuclear and heteronuclear NMR spectroscopy, chemical evidences, and by comparison with the published data of the closely related compounds. The glycoside 1 displayed in vitro inhibitory activity against butyrylcholinesterase (BChE) enzyme with IC50 value of 21.2 ± 0.01 μM.

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Polish Journal of Chemistry

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