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Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

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Authors

Ambrus, Joseph
Halliday, Jill
Kanizaj, Nicholas
Absalom, Nathan
Harpsoe, Kaspar
Balle, Thomas
Chebib, Mary
McLeod, Malcolm

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Publisher

Royal Society of Chemistry

Abstract

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

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Citation

Source

Chemical Communications

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Restricted until

2037-12-31