Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides
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Ambrus, Joseph
Halliday, Jill
Kanizaj, Nicholas
Absalom, Nathan
Harpsoe, Kaspar
Balle, Thomas
Chebib, Mary
McLeod, Malcolm
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Royal Society of Chemistry
Abstract
The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).
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Chemical Communications
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2037-12-31
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