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Pathways for self-tolerance and the treatment of autoimmune diseases

Date

Authors

Goodnow, Christopher

Publisher

Lancet Publishing Group

Abstract

Antigen delivers both immunogenic and tolerogenic signals to lymphocytes. The outcome of antigen exposure represents a complex integration of the timing of antigen binding with signals from many other immunogenic and tolerogenic costimulatory pathways. A

Keywords

Keywords: antigen; B lymphocyte receptor; CD40 antigen; corticosteroid; cyclosporin A; Fas antigen; immunoglobulin enhancer binding protein; immunomodulating agent; interleukin 2; interleukin 4; ligand; lipopolysaccharide; lymphocyte antigen receptor; protein; prot

URI

http://hdl.handle.net/1885/64976

Collections

Open Access Research

Source

Lancet, The (UK edition)

Type

Journal article

DOI

10.1016/S0140-6736(00)05185-0

Restricted until

2037-12-31

Downloads

File

Description

01_Goodnow_Pathways_for_self-tolerance_2001.pdf (113.82 KB)