A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation

Ahmed, Jehangir; Ali, Radiya; Warr, Nicholas; Wilson, Heather; Bellchambers, Helen; Barratt, Kristen; Thompson, Amelia; Arkell, Ruth

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A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation

Date

2013

Authors

Ahmed, Jehangir

Ali, Radiya

Warr, Nicholas

Wilson, Heather

Bellchambers, Helen

Barratt, Kristen

Thompson, Amelia

Arkell, Ruth

Publisher

The Company of Biologists Ltd

Abstract

The ZIC transcription factors are key mediators of embryonic development and ZIC3 is the gene most commonly associated with situs defects (heterotaxy) in humans. Half of patient ZIC3 mutations introduce a premature termination codon (PTC). In vivo, PTC-co