Radical Carboxyarylation Approach to Lignans. Total Synthesis of (-)-Arctigenin, (-)-Matairesinol, and Related Natural Products

Fischer, Joshua; Reynolds, Aaron; Sharp, Lisa; Sherburn, Michael

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Radical Carboxyarylation Approach to Lignans. Total Synthesis of (-)-Arctigenin, (-)-Matairesinol, and Related Natural Products

Date

2004

Authors

Fischer, Joshua

Reynolds, Aaron

Sharp, Lisa

Sherburn, Michael

Publisher

American Chemical Society

Abstract

Total syntheses of seven biologically important lignan natural products, including (-)-arctigenin, (-)-matairesinol, and (-)α-conidendrin, by way of a highly stereoselective domino radical sequence is presented. The reported stereochemistry of the natura