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A consensus epitope prediction approach identifies the breadth of murine T CD8+ -cell responses to vaccinia virus

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Date

2006

Authors

Moutaftsi, Magdalini
Peters, Bjoern
Pasquetto, Valerie
Tscharke, David
Sidney, John
Bui, Huynh-Hoa
Grey, Howard
Sette, Alessandro

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.

Description

Keywords

Keywords: Algorithms; Antigens; Biomarkers; Biotechnology; Cell culture; Mathematical models; Viruses; Breadth; Consensus epitopes; Predicitve algorithms; T-cell; Cells; cytokine; DNA polymerase; epitope; gamma interferon; major histocompatibility antigen class 1;

Citation

URI

http://hdl.handle.net/1885/28900

Collections

Open Access Research

Source

Nature Biotechnology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/nbt1215

Restricted until

2037-12-31

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01_Moutaftsi_A_consensus_epitope_prediction_2006.pdf (164.23 KB)

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