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Lipotoxicity, β cell dysfunction, and gestational diabetes

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Date

2014-04-01

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Abstract

Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.

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URI

https://dspace-test.anu.edu.au/handle/1885/733748437

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DevOps Pure Testing

Source

Cell Metabolism

Type

Short survey

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DOI

10.1016/j.cmet.2014.03.020

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