Test environment running 7.6.6

Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Assembling branched and macrocyclic peptides on proteins

Thumbnail Image

Date

2025-01-17

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

A two-step, biocompatible strategy enables site-specific generation of branched and macrocyclic peptide–protein conjugates. Solvent-exposed cysteines on proteins are modified by a small bifunctional reagent at near-physiological pH, followed by cyanopyridine–aminothiol click reactions to create branched or macrocyclic peptide architectures. This method offers design strategies for next-generation protein therapeutics.

Description

Keywords

Citation

URI

https://dspace-test.anu.edu.au/handle/1885/733739337

Collections

DevOps Pure Testing

Source

Chemical Communications

Type

Article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1039/d4cc06442a

Restricted until

DSpace software copyright © 2002-2026 LYRASIS