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Different Preparations of Intravenous Immunoglobulin Vary in Their Efficacy to Neutralize Streptococcal Superantigens: Implications for Treatment of Streptococcal Toxic Shock Syndrome

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Date

2006

Authors

Schrage, Birgit
Duan, Guowen (Tony)
Yang, Lily
Fraser, John D.
Proft, Thomas

Journal Title

Journal ISSN

Volume Title

Publisher

University of Chicago Press

Abstract

Eight different batches of intravenous immunoglobulin from 3 different manufacturers were tested for neutralizing activities against all currently known streptococcal superantigens. Statistically significant variation among different intravenous immunoglobulin preparations (P < .0001) and between individual streptococcal superantigens (P < .0001) was observed. These results might be helpful for optimizing the type and dose of intravenous immunoglobulin used in adjunctive therapy for severe invasive streptococcal disease.

Description

Keywords

Keywords: endobulin d; endobulin s; immunoglobulin; intragam p; neutralizing antibody; Streptococcus antigen; vigam s; adjuvant therapy; article; controlled study; dose response; drug efficacy; drug synthesis; human; human cell; priority journal; single drug dose;

Citation

URI

http://hdl.handle.net/1885/38787

Collections

Open Access Research

Source

Clinical Infectious Diseases

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1086/507037

Restricted until

2037-12-31

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Description
01_Schrage_Different_Preparations_of_2006.pdf (143.05 KB)

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