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A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction

Date

Authors

Kimura, Takashi

Pace, Suzy M

Wei, Lan

Beard, Nicole

Dirksen, Robert

Dulhunty, Angela

Publisher

Portland Press

Abstract

The aim of the present study was to examine residues that are variably spliced in the juvenile and adult isoforms of the skeletal-muscle RyR1 (type 1 ryanodine receptor). The juvenile ASI(-) splice variant is less active than the adult ASI(+) variant and

Keywords

Keywords: Binding partners; Juvenile isoform; Ryanodine binding; Sarcoplasmic reticulum vesicles; Blood vessels; Muscle; Proteins; Biochemistry; binding protein; glycine; isoprotein; peptide pasi; ryanodine receptor 1; threonine; tritium; unclassified drug; alterna Alternative splicing; Inter-domain interaction; Myotonic dystrophy; Single channel recording; Skeletal ryanodine receptor; Synthetic peptide

URI

http://hdl.handle.net/1885/25063

Collections

Open Access Research

Source

Biochemical Journal

Type

Journal article

DOI

10.1042/BJ20060686

Restricted until

2037-12-31

Downloads

File

Description

01_Kimura_A_variably_spliced_region_in_2007.pdf (471.35 KB)