Winter temperature and myocardial infarction in Brisbane, Australia

Abstract

Myocardial infarction (MI) incidence often peaks in winter, but it remains unclear how winter temperature affects MI temporally and spatially. We examined the short-term effects of winter temperature on the risk of MI and explored spatial associations of winter MI hospitalizations with temperature and socioeconomic status (area-based index) in Brisbane, Australia. We used a distributed lag non-linear model to fit the association at the city level between population-weighted daily mean temperature and daily MI hospitalizations during 11 winters of 2005–2015. For each winter, a Bayesian spatial conditional autoregressive model was fitted to examine the associations at postal code level of MI hospitalisations with temperature and socioeconomic status measured as the Index of Relative Socio-Economic Advantage and Disadvantage (IRSAD). Area-specific winter temperature was categorised into three levels: cold (<25th percentile of average winter temperature across postal areas), mild (25th–75th percentile) and warm (>75th percentile). This study included 4978 MI hospitalizations. At the city level, each 1 °C drop in temperature below a threshold of 15.6 °C was associated with a relative risk (RR) of 1.016 (95% confidence interval (CI): 1.008–1.024) for MI hospitalizations on the same day. Low temperature had a much delayed and transient effect on women but an immediate and longer-lasting effect on men. Winter MI incidence rate varied spatially in Brisbane, with a higher incidence rate in warmer areas (RR for mild areas: 1.214, 95%CI: 1.116–1.320; RR for warm areas: 1.251, 95%CI: 1.127–1.389; cold areas as the reference) and in areas with lower socioeconomic levels (RR: 0.900, 95%CI: 0.886–0.914 for each decile increase in IRSAD). This study provides compelling evidence that short-term winter temperature drops were associated with an elevated risk of MI in the subtropical region with a mild winter. Particular attention also needs to be paid to people living in relatively warm and socioeconomically disadvantaged communities in winter. Show more