Probing the closed-loop model of mRNA translation in living cells

Archer, Stuart; Shirokikh, Nikolay; Hallwirth, Claus; Beilharz, Traude; Preiss, Thomas

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Probing the closed-loop model of mRNA translation in living cells

Date

2015

Authors

Archer, Stuart

Shirokikh, Nikolay

Hallwirth, Claus

Beilharz, Traude

Preiss, Thomas

Publisher

Landes Bioscience

Abstract

The mRNA closed-loop, formed through interactions between the cap structure, poly(A) tail, eIF4E, eIF4G and PAB, features centrally in models of eukaryotic translation initiation, although direct support for its existence in vivo is not well established.