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Regulation of γ-glutamylcysteine utilization in erythrocytes

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Date

1980

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Abstract

Glutathione is synthesized from γ-glutamylcysteine and glycine via the action of glutathione synthetase. It is known that γ-glutamylcyclotransferase is present in many cells and may convert γ-glutamylcysteine to 5-oxoproline and cysteine, but until now there has not been a credible explanation for the apparent suppression of the γ-glutamylcyclotransferase reaction during glutathione synthesis. Our data suggest that the γ-glutamylcyclotransferase and glutathione synthetase pathways are regulated by a simple kinetic mechanism that favors the synthesis of glutathione.

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Citation

URI

https://dspace-test.anu.edu.au/handle/1885/733741711

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DevOps Pure Testing

Source

Enzyme

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Article

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DOI

10.1159/000459258

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