Alloreactive Cytotoxic T Lymphocytes Lyse Syngeneic Influenza‐Infected Tumour Cell Targets

Abstract

Spleen cells from C57BL/10(H‐2b) mice, when stimulated in vitro to Kk alloantigens, lysed syngeneic influenza A virus‐infected tumour cell targets but not uninfected or vaccinia‐ or Sendai virus‐infected targets. Peritoneal macrophage targets infected with influenza virus were not lysed. Lysis of H‐2k targets and EL4‐A influenza virus‐infected targets was abrogated by treatment of effectors with anti‐Thy 1.2plusCandanti‐Lyt2plusCbut not by anti‐Lyt 1 plusC or anti‐GM‐1. a natural killer cell‐specific, monoclonal antibody plus C. Cold target inhibition experiments indicated that one and the same population of Tc cells see H‐2Kk and H‐2b plus influenza virus. Sensitization of C57BL/10 mice to Kk in vivo did not potentiate virus clearance from lungs. The data are discussed in relation to observed Ir gene effects and variation and modulation of H‐2 antigens on tumour cells. Show more