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Regression of Novikoff rat hepatocellular carcinoma following locoregional administration of a novel formulation of clofazimine in lipiodol

Date

Authors

Pourgholami, Mohammad H

Lu, Ying

Wang, Lisa

Stephens, Ross

Morris, David L

Publisher

Elsevier

Abstract

We report here that, clofazimine (CFZ) treatment (0.1-10 μM) led to inhibition of in vitro proliferation of hepatocellular carcinoma (HCC) cell lines Hep3-β, HuH-7, HepG2, SKHEP-1, PLC/PRF-5 and Novikoff. A 24 h exposure of human HuH-7 cells to various

Keywords

Keywords: clofazimine; iodinated poppyseed oil; animal cell; animal experiment; animal model; animal tissue; apoptosis; article; cancer inhibition; controlled study; drug efficacy; histopathology; human; human cell; intestine; lipophilicity; liver cell carcinoma; l Clofazimine; Hepatocellular carcinoma; Lipiodol; Novikoff

URI

http://hdl.handle.net/1885/56658

Collections

Open Access Research

Source

Cancer Letters

Type

Journal article

DOI

10.1016/j.canlet.2003.11.019

Restricted until

2037-12-31

Downloads

File

Description

01_Pourgholami_Regression_of_Novikoff_rat_2004.pdf (506.38 KB)