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Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

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Date

2013

Authors

Chooi, Yit-Heng
Fang, Jinxu
Liu, Hong
Filler, Scott G
Wang, Pin
Tang, Yi

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/80435

Collections

Open Access Research

Source

Organic Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ol303435y

Restricted until

2037-12-31

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01_Chooi_Genome_mining_of_a_prenylated_2013.pdf (1.2 MB)

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