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CD4+ T Cells Modulate Expansion and Survival but Not Functional Properties of Effectror and Memory CD8+ T Cells Induced by Malaria Sporozoites

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Overstreet, Michael G
Chen, Yun-Chi
Cockburn, Ian
Tse, Sze-Wah
Zavala, Fidel

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Public Library of Science

Abstract

CD4+ helper T cells are critical orchestrators of immune responses to infection and vaccination. During primary responses, naïve CD8+ T cells may need "CD4 help" for optimal development of memory populations. The immunological factors attributed to CD4 h

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PLOS ONE (Public Library of Science)

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Restricted until

2037-12-31