107. Quinazolines. Part IV. Covalent hydration in the cations of substituted quinazolines

Abstract

Twenty mono(Bz-)substituted quinazolines have been prepared, some by conventional routes, but ten of them by alkaline decomposition of appropriately substituted 4-(N′-toluene-p-sulphonylhydrazino)quinazolines made from the corresponding 4-chloroquinazolines. The ionization constants and ultraviolet spectra reveal many examples of stable covalent hydration in the cation. The kinetics of dehydration of some (unstable) hydrated neutral molecules have been measured and used to throw light on the degree of hydration in the cation. The relation between hydration and the positions and nature of the substituents is discussed. Show more