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Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes

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Date

2007

Authors

Nekrasov, Maxim
Klymenko, Tetyana
Fraterman, Sven
Papp, Bernadett
Oktaba, Katarzyna
Kocher, Thomas
Cohen, Adrian
Stunnenberg, Hendrik G
Wilm, Matthias
Muller, Jurg

Journal Title

Journal ISSN

Volume Title

Publisher

Oxford University Press

Abstract

PRC2 is thought to be the histone methyltransferase (HMTase) responsible for H3-K27 trimethylation at Polycomb target genes. Here we report the biochemical purification and characterization of a distinct form of Drosophila PRC2 that contains the Polycomb

Description

Keywords

Keywords: histone methyltransferase; isoenzyme; isoprotein; polycomb group protein; protein h3 k27; protein pcl prc2; unclassified drug; article; chromatin; complex formation; controlled study; DNA responsive element; Drosophila; embryo; functional proteomics; gene Drosophila; Gene silencing; Histone methylation; PcG; trxG

Citation

URI

http://hdl.handle.net/1885/53895

Collections

Open Access Research

Source

EMBO Journal, The

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/sj.emboj.7601837

Restricted until

2037-12-31

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Description
01_Nekrasov_Pcl-PRC2_is_needed_to_generate_2007.pdf (476.56 KB)

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