Interferon alfa-2b for chronic active hepatitis C

Abstract

• ■ Interferon produced a complete response in about 70% and a partial response (≥25% reduction ALT) in the remainder of patients treated with Interferon alfa-2b. • ■ Spontaneous, complete or partial resolution of ALT abnormality did not occur in untreated patients. • ■ The fall in serum ALT reflects reduced necroinflammation in liver biopsy. • ■ Six months after interferon, complete remission was sustained for 2 months or more in 40% of patients. • ■ The onset of relapse was often associated with acute hepatitis of greater severity than pretreatment illness. Show more