Peptide Ligation-Desulfurization Chemistry at Arginine

Malins, Lara R.; Cergol, Katie M.; Payne, Richard J.

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Peptide Ligation-Desulfurization Chemistry at Arginine

Date

2013

Authors

Malins, Lara R.

Cergol, Katie M.

Payne, Richard J.

Abstract

The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.