Test environment running 7.6.6

Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

CTLA-4 and multiple sclerosis

Thumbnail Image

Date

2008-05-30

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.

Description

Keywords

Cytotoxic T lymphocyte-associated antigen-4, Genetic association, Major histocompatibility complex, Multiple sclerosis

Citation

URI

https://dspace-test.anu.edu.au/handle/1885/733742300

Collections

DevOps Pure Testing

Source

Journal of Neuroimmunology

Type

Article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.jneuroim.2008.02.001

Restricted until

DSpace software copyright © 2002-2026 LYRASIS