Over-diagnosis of rotavirus infection in infants due to detection of vaccine virus

Whiley, David M.; Ye, Suifang; Tozer, Sarah; Clark, Julia E.; Bletchly, Cheryl; Lambert, Stephen B.; Grimwood, Keith; Nimmo, Graeme R.

Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Over-diagnosis of rotavirus infection in infants due to detection of vaccine virus

Date

2020-09-01

Authors

Abstract

An accurate rotavirus diagnosis is important for clinical management and monitoring active disease and vaccine effectiveness. Between 2016-2018, rotavirus-positive results in our laboratory were from vaccine virus shedding in 71/152 (46.7%) infants with a request for rotavirus testing. Routine infant diagnostic testing should ideally distinguish vaccine from wild-type viruses.