Microwave assisted synthesis and antibacterial study of 3-naphthyl-2-[(un)substituted phenyl]-1,3-thiazolidin-4-ones

Abstract

A series of 3-naphthyl-2-[(un)substituted phenyl]-1,3-thiazolidin-4-ones were synthesized by the three-component one-pot cyclocondensation of naphthylamine, aromatic aldehyde and 2-mercaptoacetic acid using a microwave-assisted method in the presence of DMAP/DCC. This reaction has such advantages as short reaction time, simple procedure and mild condition. The structures of the synthesized compounds were confirmed by IR, NMR, MS spectra and elemental analysis. Antibacterial (Pseudomonas springae pv. lachrymans (Smith et Bryan) Young, Dye & Wilkie, Botrytis cinerea Pers., and Sphaerotheca fusca Blum.) activities of the compounds were evaluated, and some of them showed notable inhibition against Sphaerotheca fusca Blum. Show more