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The role of ring D in the antitumor antibiotic streptonigrin: metal complexation, DNA binding and topoisomerase inhibition by ABC ring analogues of streptonigrin

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Date

2001

Authors

Anderberg, Pia I
Harding, Margaret

Journal Title

Journal ISSN

Volume Title

Publisher

Cognizant Communication Corporation

Abstract

The interaction of 7-amino-2-(6′-carboxy-2′-pyridyl)-6-methoxy-5,8-quinolinedione, an ABC ring analogue of the antitumour antibiotic streptonigrin, with zinc(II), oligonucleotides and DNA in the presence of zinc(II), and on the relaxation of DNA by to

Description

Keywords

Keywords: 7 amino 2 (6' carboxy 2' pyridyl) 6 methoxy 5,8 quinolinedione; DNA; DNA topoisomerase; DNA topoisomerase (ATP hydrolysing); phenol derivative; rufocromomycin; unclassified drug; zinc derivative; aqueous solution; article; chemical interaction; complex fo Amhloquinone; Anticancer; Bipyridyl; Drug-DNA complex; Streptonigrin; Topoisomerase

Citation

URI

http://hdl.handle.net/1885/73513

Collections

Open Access Research

Source

Anti-Cancer Drug Design

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

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