2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA A  receptors

Karim, Nasiara; Curmi, John; Gavande, Navnath; Johnston, Graham A R; Hanrahan, Jane R; Tierney, Mary (Louise); Chebib, Mary

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2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA A receptors

Date

2012

Authors

Karim, Nasiara

Curmi, John

Gavande, Navnath

Johnston, Graham A R

Hanrahan, Jane R

Tierney, Mary (Louise)

Chebib, Mary

Publisher

Nature Publishing Group

Abstract

BACKGROUND AND PURPOSE Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate this further. EXPERIMENTAL APPROACH We evaluated the effects of 2′-methoxy-6-methylflavone (2