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Mechanisms of prion-induced modifications in membrane transport properties: Implications for signal transduction and neurotoxicity

Date

Authors

Kourie, Joseph

Publisher

Elsevier

Abstract

Prion-related encephalopathies are associated with the conversion of a normal cellular isoform of prion protein (PrPc) to an abnormal pathologic scrapie isoform (PrPSc). The conversion of this single polypeptide chain involves a reduction in the α-helice

Keywords

Keywords: 4 aminobutyric acid; adenosine triphosphatase; amino acid; calcineurin; calcium channel L type; calcium ion; calmodulin; copper ion; diltiazem; ion channel; isoprotein; magnesium ion; n methyl dextro aspartic acid; nifedipine; polypeptide; prion protein; Amyloidosis; Ion channel pathologies; Ion channel-forming peptides; Membrane physiology; Neurodegenerative diseases; Prion diseases

URI

http://hdl.handle.net/1885/90564

Collections

Open Access Research

Source

Chemico-Biological Interactions

Type

Journal article

DOI

10.1016/S0009-2797(01)00228-9

Restricted until

2037-12-31

Downloads

File

Description

01_Kourie_Mechanisms_of_prion-induced_2001.pdf (567.07 KB)