Preliminary X-ray Crystallographic and NMR Studies on the Exonuclease Domain of the e Subunit of Escherichia coli DNA Polymerase III

Hamdan, Samir; Brown, Susan Elizabeth; Thompson, Phillip; Yang, Ji Yeon; Carr, Paul D; Ollis, David; Otting, Gottfried; Dixon, Nicholas

Preliminary X-ray Crystallographic and NMR Studies on the Exonuclease Domain of the e Subunit of Escherichia coli DNA Polymerase III

Date

2000

Authors

Hamdan, Samir

Brown, Susan Elizabeth

Thompson, Phillip

Yang, Ji Yeon

Carr, Paul D

Ollis, David

Otting, Gottfried

Dixon, Nicholas

Publisher

Academic Press

Abstract

The structured core of the N-terminal 3'-5' exonuclease domain of ε, the proofreading subunit of Escherichia coli DNA polymerase III, was defined by multidimensional NMR experiments with uniformly15N-labeled protein: it comprises residues between IIe-4 a