Disentangling fetal insulin hypersecretion and insulin resistance

Nolan, Christopher J.; Desoye, Gernot

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Disentangling fetal insulin hypersecretion and insulin resistance

Date

2024

Authors

Nolan, Christopher J.

Desoye, Gernot

Abstract

Disentangling which of insulin hypersecretion and insulin resistance is upstream in obesity-related type 2 diabetes (T2D) is challenging. Here, we consider the dynamics of insulin secretion and action in the fetuses of mothers with diabetes. We argue that fetal insulin hypersecretion occurs first, with insulin resistance being an adaptive protective response.