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Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice

Date

Authors

de Jersey, James

Snelgrove, Sarah L

Palmer, Stephanie

Teteris, Simon

Mullbacher, Arno

Miller, Jacques

Slattery, Robyn

Publisher

National Academy of Sciences (USA)

Abstract

Type 1 diabetes (T1D) is caused by the destruction of insulin-producing islet β cells. CD8 T cells are prevalent in the islets of T1D patients and are the major effectors of β cell destruction in nonobese diabetic (NOD) mice. In addition to their critic

Keywords

Keywords: beta 2 microglobulin; animal cell; animal experiment; animal model; antigen expression; antigen presenting cell; article; autoimmunity; CD8+ T lymphocyte; controlled study; female; flow cytometry; gene inactivation; gene targeting; insulin dependent diabe Antigen-presenting cells; Autoimmunity; Insulitis; Type 1 diabetes

URI

http://hdl.handle.net/1885/21797

Collections

Open Access Research

Source

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Type

Journal article

DOI

10.1073/pnas.0610057104

Restricted until

2037-12-31

Downloads

File

Description

01_de Jersey_Beta_cells_cannot_directly_2007.pdf (2.69 MB)