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Channels formed with a mutant prion protein PrP(82-146) homologous to a 7-kDa fragment in diseased brain of GSS patients

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Date

2003

Authors

Bahadi, Randa
Farrelly, Peter
Kenna, Bronwyn
Kourie, Joseph
Tagliavini, Fabrizio
Forloni, Gianluigi
Salmona, Mario

Journal Title

Journal ISSN

Volume Title

Publisher

American Physiological Society

Abstract

A major prion protein (PrP) mutant that forms amyloid fibrils in the diseased brain of patients with Gerstmann-Sträussler-Scheinker syndrome (GSS) is a fragment of 7 kDa spanning from residues 81-82 to 144-153 of PrP. Analysis of ionic membrane currents,

Description

Keywords

Keywords: copper ion; ion channel; mutant protein; prion protein; rifampicin; amino acid sequence; article; Gerstmann Straussler Scheinker syndrome; human; lipid bilayer; lipid membrane; membrane current; nerve cell membrane; neurotoxicity; priority journal; sequen Amyloids; Cytotoxic proteins; Membrane-linked pathologies; Neurodegenerative diseases; Prion channels; Prion diseases; Vacuolation

Citation

URI

http://hdl.handle.net/1885/88488

Collections

Open Access Research

Source

American Journal of Physiology - Cell Physiology

Type

Journal article

Book Title

Entity type

Access Statement

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DOI

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