A chemoenzymatic total synthesis of the protoilludane aryl ester (+)-Armillarivin

Schwartz, BrettMatousova, EliskaWhite, RichardBanwell, MartinWillis, Anthony2015-12-101523-7060http://hdl.handle.net/1885/61959The title natural product, 1, has been synthesized in 20 steps from the enantiomerically pure cis-1,2-dihydrocatechol 2, itself obtained through the whole-cell biotransformation of toluene. The pivotal steps in the reaction sequence involve a Diels-AlderA chemoenzymatic total synthesis of the protoilludane aryl ester (+)-Armillarivin201310.1021/ol400583c2015-12-10