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Enzymatic racemic resolution of a fluorinated substrate and syntheses of E and Z alkenes as precursors for some biologically active fluorohexoses

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dc.contributor.authorAli, Muhammad Shaiqen
dc.contributor.authorKitazume, Tomoyaen
dc.contributor.authorAhmad, Viqar Uddinen
dc.date.accessioned2025-03-23T06:26:00Z
dc.date.available2025-03-23T06:26:00Z
dc.date.issued1997en
dc.description.abstractA fluorinated substrate 6 was prepared and then the enantiomers (6a and 7a) were separated by an enzyme in presence of an acetylating agent. The optical purity of 6a and 7a were determined by derivatising them into their MTPA-esters and then by taking their 19F NMR spectra. It was observed that, PL 266 (enzyme), benzene (solvent), 24 h (time), 40 °C (temp.) and vinyl acetate (acetylating agent) were the ideal conditions for racemic resolution. The optical purity was further improved by changing the solvent (hexane), amount of enzyme (PL 266; 3000 units), reaction time (12 h) and amount of acetylating agent (vinyl acetate; two molar). The optically pure species was used for the preparation of E and Z alkenes.en
dc.description.sponsorshipThe financial support from UNESCO of Japan is gratefully acknowledged.en
dc.description.statustrueen
dc.format.extent6en
dc.identifier.otherScopus:0040564585en
dc.identifier.urihttps://dspace-test.anu.edu.au/handle/1885/733731320
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=0040564585&partnerID=8YFLogxKen
dc.language.isoEnglishen
dc.sourceZeitschrift fur Naturforschung - Section B Journal of Chemical Sciencesen
dc.subjectAlkenesen
dc.subjectEnzymatic Racemic Resolutionen
dc.subjectFluorinated substrateen
dc.titleEnzymatic racemic resolution of a fluorinated substrate and syntheses of E and Z alkenes as precursors for some biologically active fluorohexosesen
dc.typeArticleen
local.bibliographicCitation.lastpage418en
local.bibliographicCitation.startpage413en
local.contributor.affiliationAli, Muhammad Shaiq; University of Karachien
local.contributor.affiliationKitazume, Tomoya; Institute of Science Tokyoen
local.contributor.affiliationAhmad, Viqar Uddin; University of Karachien
local.identifier.citationvolume52en
local.identifier.doi10.1515/znb-1997-0320en
local.identifier.pure6b7cfd73-dc34-46ee-9ef0-bcd43e428d40en
local.type.statusPublisheden

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