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Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

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Date

2006

Authors

Lee, Connie
Easton, Christopher
Savage, G Paul
Simpson, Gregory Wayne

Journal Title

Journal ISSN

Volume Title

Publisher

ARKAT Foundation

Abstract

Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.

Description

Keywords

Keywords: Acetylcholinesterase; Alzheimer's disease; Cycloadditions; Isoxazolines; Nitrile oxides; Quinuclidine

Citation

URI

http://hdl.handle.net/1885/79744

Collections

Open Access Research

Source

ARKIVOC

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

2037-12-31

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Description
01_Lee_Synthesis_of_spiroisoxazolines_2006.pdf (282.31 KB)

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