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Increased permeability of the malaria-infected erythrocyte to organic cations

Date

Authors

Staines, H

Rae, Caroline

Kirk, Kiaran

Publisher

Elsevier

Abstract

The human malaria parasite, Plasmodium falciparum, induces in the plasma membrane of its host red blood cell new permeation pathways (NPP) that allow the influx of a variety of low molecular weight solutes. In this study we have demonstrated that the NPP

Keywords

Keywords: cation; choline; phenyltrimethylammonium; quaternary ammonium derivative; tetrabutylammonium; tetramethylammonium; tetrapentylammonium; tetrapropylammonium; tetrylammonium; article; controlled study; drug structure; erythrocyte; hemolysis; human; human ce Channel; Induced transport; Membrane permeability; Plasmodium falciparum; Selectivity

URI

http://hdl.handle.net/1885/88825

Collections

Open Access Research

Source

Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics

Type

Journal article

DOI

10.1016/S0005-2736(99)00187-X

Restricted until

2037-12-31

Downloads

File

Description

01_Staines_Increased_permeability_of_the_2000.pdf (278.23 KB)