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Differentiation-defective mutants of mouse embryonal carcinoma cells

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dc.contributor.authorMcCue, Peter A.en
dc.contributor.authorMatthaei, Klaus I.en
dc.contributor.authorTaketo, Makotoen
dc.contributor.authorSherman, Michael I.en
dc.date.accessioned2025-03-25T00:24:41Z
dc.date.available2025-03-25T00:24:41Z
dc.date.issued1983en
dc.description.abstractWe have generated by mutagenesis eight differentiation-defective sublines from three murine embryonal carcinoma (EC) cell lines. These mutants grossly resemble parental cells in the absence of inducers of differentiation. Based upon response to retinoic acid (RA) or hexamethylenebisacetamide (HMBA), the mutants can be grouped into three types: (a) RA-selected cells that lack cellular RA binding protein (cRABP) activity and fail to differentiate in response to RA or HMBA; (b) RA- or HMBA-selected cells that possess cRABP but differentiate poorly, if at all, in the presence of RA or HMBA; and (c) cells originally selected for lack of response to HMBA but which retain cRABP and the ability to differentiate in response to RA.en
dc.description.sponsorshipWe wish to thank Ms. M. L. Paternoster for technical assistance, Drs. A. J. Shatkin, B. Cohen and M. Eglitis for comments on the manuscript, Drs. C. Perry and A. Liebman for [3H]RA, and Drs. D. Solter and B. Pierce for gifts of antibody. P.A.M. is a Fellow in the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, and is supported by a National Research Service Award from the National Cancer Institute.en
dc.description.statustrueen
dc.format.extent11en
dc.identifier.otherScopus:0020522623en
dc.identifier.otherPubMed:6299821en
dc.identifier.urihttps://dspace-test.anu.edu.au/handle/1885/733735695
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=0020522623&partnerID=8YFLogxKen
dc.language.isoEnglishen
dc.sourceDevelopmental Biologyen
dc.titleDifferentiation-defective mutants of mouse embryonal carcinoma cellsen
dc.typeArticleen
local.bibliographicCitation.lastpage426en
local.bibliographicCitation.startpage416en
local.contributor.affiliationMcCue, Peter A.; Hoffmann-La Roche Inc.en
local.contributor.affiliationMatthaei, Klaus I.; Hoffmann-La Roche Inc.en
local.contributor.affiliationTaketo, Makoto; Hoffmann-La Roche Inc.en
local.contributor.affiliationSherman, Michael I.; Hoffmann-La Roche Inc.en
local.identifier.citationvolume96en
local.identifier.doi10.1016/0012-1606(83)90179-3en
local.identifier.purefd7ecb53-2147-437f-9652-002b9199ecc1en
local.type.statusPublisheden

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