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Mice deficient in the alpha subunit of G(z) show changes in pre-pulse inhibition, anxiety and responses to 5-HT1A receptor stimulation, which are strongly dependent on the genetic background

Date

Authors

van den Buuse, Maarten

Martin, Sally

Holgate, Joan

Matthaei, Klaus

Hendry, Ian

Publisher

Springer

Abstract

Rationale: Gz, a member of the Gi G protein family, is involved in the coupling of dopaminergic and serotonergic receptors. In the present study, we investigated behaviour of mice deficient in the α subunit of Gz and focused on pre-pulse inhibition (PPI)

Keywords

Keywords: guanine nucleotide binding protein alpha subunit; gz subunit; serotonin 1A receptor; unclassified drug; animal behavior; animal experiment; animal model; anxiety; article; Bagg albino mouse; C57BL 6 mouse; controlled study; enzyme deficiency; female; here 5-HT1A receptors; G protein; Gz; Knock-out mice; Plus maze; Pre-pulse inhibition; Serotonin; Strain differences

URI

http://hdl.handle.net/1885/29663

Collections

Open Access Research

Source

Psychopharmacology

Type

Journal article

DOI

10.1007/s00213-007-0888-7

Restricted until

2037-12-31

Downloads

File

Description

01_van den Buuse_Mice_deficient_in_the_alpha_2007.pdf (327.13 KB)