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Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release

Date

Authors

Dulhunty, Angela

Curtis, Suzanne

Cengia, Louise

Sakowska, Magdalena

Casarotto, Marco

Publisher

Portland Press

Abstract

We show that peptide fragments of the dihydropyridine receptor II-III loop alter cardiac RyR (ryanodine receptor) channel activity in a cytoplasmic Ca 2+-dependent manner. The peptides were Ac (Thr-793-Ala-812 of the cardiac dihydropyridine receptor), As

Keywords

Keywords: Biochemistry; Cytology; Lipids; Nuclear magnetic resonance; Plasmas; Cytoplasmic; Helical; Peptide fragments; Sarcoplasmic; Cardiology; 1,4 dihydropyridine receptor; alanine; heart receptor; ion channel; leucine; peptide fragment; protein subunit; threoni Cardiac ryanodine receptor activity; Dihydropyridine receptor; Muscle contraction; Ryanodine receptor probe

URI

http://hdl.handle.net/1885/85446

Collections

Open Access Research

Source

Biochemical Journal

Type

Journal article

DOI

10.1042/BJ20031096

Restricted until

2037-12-31

Downloads

File

Description

01_Dulhunty_Peptide_fragments_of_the_2004.pdf (392.19 KB)