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Characterization of the Stability and Bio-functionality of Tethered Proteins on Bioengineered Scaffolds: Implications for stem cell biology and tissue repair

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Date

2014

Authors

Wang, Ting-Yi
Bruggeman, Kiara
Sheean, Rebecca K
Turner, Bradley
Nisbet, David
Parish, Clare L.

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

Background: Tethering proteins onto bioengineered scaffolds enables longterm delivery, however protein stability, release kinetics, and functionality over time remains unknown. Results: Tethered proteins remain stable and functional for several months, capable of activating intracellular signaling pathways and influencing cell fate. Conclusion: Tethered proteins are stable and functional long-term. Significance: Such knowledge may have implications for promoting tissue repair.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/70806

Collections

Open Access Research

Source

Journal of Biological Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1074/jbc.M113.537381

Restricted until

2037-12-31

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01_Wang_Characterization_of_the_2014.pdf (1.39 MB)

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