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Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats

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Date

2000

Authors

Harvey, Peta
Gready, Jill
Yin, Zhan-Li
Le Couteur, D
McLean, Allan

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Pharmacology and Experimental Therapeutics

Abstract

The oxygen limitation hypothesis states that hepatocyte hypoxia is the mechanism determining metabolic restriction in the cirrhotic liver. Therefore we studied markers of hepatocyte energy state and cellular hypoxia in livers of normal and cirrhotic rats

Description

Keywords

Keywords: adenosine diphosphate; adenosine triphosphate; lactic acid; oxygen; perchloric acid; pyruvic acid; animal cell; animal experiment; animal tissue; article; blood gas analysis; cell hypoxia; controlled study; energy metabolism; liver cell; liver cirrhosis;

Citation

URI

http://hdl.handle.net/1885/88897

Collections

Open Access Research

Source

Journal of Pharmacology and Experimental Therapeutics

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

2037-12-31

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Description
01_Harvey_Acute_Oxygen_Supplementation_2000.pdf (77.6 KB)

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