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Type 2 Cytokines in the Pathogenesis of Sustained Airway Dysfunction and Airway Remodeling in Mice

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Date

2004

Authors

Leigh, Richard
Ellis, Russ
Wattie, Jennifer
Hirota, Jeremy
Matthaei, Klaus
Foster, Paul S
O'Byrne, Paul
Inman, Mark

Journal Title

Journal ISSN

Volume Title

Publisher

American Thoracic Society

Abstract

The mechanisms underlying airway hyperresponsiveness remain unclear, although airway inflammation and remodeling likely play important roles. We have observed sustained airway hyperreactivity and airway remodeling occurring in mice after chronic allergen

Description

Keywords

Keywords: allergen; cytokine; interleukin 13; interleukin 4; interleukin 5; animal experiment; animal tissue; article; bronchus hyperreactivity; controlled study; cytokine production; female; histopathology; long term exposure; lung lavage; morphometrics; mouse; no Allergic disease; Asthma; Interleukin-13; Interleukin-4; Interleukin-5

Citation

URI

http://hdl.handle.net/1885/86023

Collections

Open Access Research

Source

American Journal of Respiratory and Critical Care Medicine

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

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