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The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of -trans-bergamotene

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Date

2013

Authors

Lin, Hsiao-Ching
Chooi, Yit-Heng
Dhingra, Sourabh
Xu, Wei
Calvo, Ana M
Tang, Yi

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability of

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Keywords

Citation

URI

http://hdl.handle.net/1885/81463

Collections

Open Access Research

Source

Journal of the American Chemical Society

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ja312503y

Restricted until

2037-12-31

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Description
01_Lin_The_fumagillin_biosynthetic_2013.pdf (1.25 MB)

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