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Inflammation location, but not type, determines the increase in TGF-β1 and IGF-1 expression and collagen deposition in IBD intestine

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Date

2001

Authors

Lawrance, I
Maxwell, Lesley
Doe, W

Journal Title

Journal ISSN

Volume Title

Publisher

Lippincott Williams & Wilkins

Abstract

Background and Aims: Inflammatory bowel disease (IBD) is frequently complicated by extracellular matrix (ECM) changes that may result in fibrosis. Transforming growth factor (TGF)-β1 and insulin-like growth factor (IGF)-1 mediate numerous ECM changes. Ou

Description

Keywords

Keywords: collagen; collagen type 1; collagen type 2; messenger RNA; somatomedin C; transforming growth factor beta1; article; colon Crohn disease; controlled study; disease classification; electron microscopy; enteritis; extracellular matrix; fibrosis; human; huma Collagen; IGF-1; Inflammatory bowel disease; Inflammatory infiltrate; TGF-ß1

Citation

URI

http://hdl.handle.net/1885/65039

Collections

Open Access Research

Source

Inflammatory Bowel Diseases

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

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