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Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe

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Date

2008

Authors

Wang, Zhuyuan
Bonoiu, Adela
Samoc, Marek
Cui, Yiping
Prasad, Paras N

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

We report pH sensing for biological applications based on surface enhanced Raman scattering (SERS) from silver nanoparticles functionalized with 2-aminothiophenol (2-aminobenzenethiol, 2-ABT). pH-dependent SERS spectra of the attached 2-ABT molecules enable one to sense the pH over the range of 3.0-8.0. We have performed the first demonstration of SERS detection in living cells kept in different pH buffer solutions and show that the pH sensitivity is retained in that case. Thus, the nanoparticles can be used as probes delivering spatially localized chemical information from biological environments and provide a new way to monitor chemical changes at cellular level.

Description

Keywords

Keywords: Cells; Chemical analysis; Nanoparticles; Raman scattering; Silver; Cellular imaging; SERS probe; Surface enhanced Raman scattering; pH sensors; 2 aminothiophenol; nanoparticle; silver; article; biosensor; carcinoma cell; controlled study; human; human cel Cellular imaging; pH sensor; SERS probe; Surface enhanced Raman scattering

Citation

URI

http://hdl.handle.net/1885/36475

Collections

Open Access Research

Source

Biosensors and Bioelectronics

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.bios.2007.09.017

Restricted until

2037-12-31

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01_Wang_Biological_pH_sensing_based_on_2008.pdf (588.06 KB)

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