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Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

Date

Authors

Riera, Ludovico

Gariglio, Marisa

Valente, Guido

Mullbacher, Arno

Museteanu, Crisan

Landolfo, Santo

Simon, Markus M

Publisher

Wiley-VCH Verlag GMBH

Abstract

The course of mouse cytomegalovirus (MCMV) infection was compared between wild-type and mutant C57BL/6 (B6) mice deficient in either RAG-2, perforin, granzyme A, granzyme B or combinations thereof at two time points post infection (p.i.). At day 15 p.i.,

Keywords

Keywords: CD8 antigen; granzyme A; granzyme B; perforin; animal experiment; animal model; animal tissue; article; controlled study; Cytomegalovirus; cytomegalovirus infection; disease course; inflammation; lung; mouse; natural killer cell; nonhuman; pathology; prio Granzyme; Murine cytomegalovirus replication; Perforin; RAG-2

URI

http://hdl.handle.net/1885/33974

Collections

Open Access Research

Source

European Journal of Immunology

Type

Journal article

DOI

10.1002/(SICI)1521-4141(200005)30:5<1350::AID-IMMU1350>3.0.CO;2-J

Restricted until

2037-12-31

Downloads

File

Description

01_Riera_Murine_cytomegalovirus_2000.pdf (187.61 KB)