Memory Complaints in nondemented men predict future pathologic diagnosis of Alzheimer disease
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Authors
Jorm, Anthony F
Masaki, Kamal H
Davis, D J
Hardman, J
Nelson, J
Markesbery, W R
Petrovitch, Helen
Ross, G Webster
White, Lon R
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Lippincott Williams & Wilkins
Abstract
The validity of memory complaints as a predictor of Alzheimer disease (AD) was assessed in 237 Japanese-American men autopsied at ages 74 to 97 years. These men were free of dementia at the time memory complaints were assessed 1 to 11 years earlier. Memory complaints were found to predict the neuropathologic diagnosis of AD after adjusting for age, time to death, education, depression, and cognitive functioning.
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Neurology