Towards the Total Synthesis of Vibsanin E, 15-O Methylcyclovibsanin B, 3-Hydroxyvibsanin E, Furanovibsanin A, and 3-O Methylfuranovibsanin A

Abstract

Studies detailing synthetic approaches to a variety of biosynthetically related vibsanin-type diterpenes (i.e. vibsanin E, 15-O-methylcyclovibsanin B, 3-hydroxy-vibsanin E, furanovibsanin A, and 3-O-methylfuranovibsanin A) are discussed. Biogenetically modelled approaches are coupled with an investigation of classical and modern six- to seven-membered ring-expansion protocols, which gain access to the central core of these natural products. Show more